In particular, they are involved in fusion of the viral membrane to the host cell, viral replication, as well as endocytosis and exocytosis ( 6). Lipids are essential cell components of SARS-CoV2. It mediates the viral entry into host cells through binding its receptor-binding domain (RBD) comprised within the S1 subunit to angiotensin-converting enzyme 2 (ACE2) as host receptor, and then by fusing the viral and host membranes through the S2 subunit ( 6). Among them, the S protein plays the most important roles in viral attachment, fusion and entry.
SARS-CoV-2 is an enveloped virus surrounded by a lipid bilayer, with a genome of approximately 30.000 nucleotides, encoding four structural proteins: the spike (S) protein, the envelope (E) protein, the membrane (M) protein and the nucleocapsid (N) protein ( 5). On 11 March 2020, the World Health Organization (WHO) finally declared COVID-19 as a pandemic disease. The epidemic spread quickly in Asia and subsequently in the rest of the world, affecting several millions people and causing thousands of deaths. Deep sequencing analysis from lower respiratory tract samples indicated a novel coronavirus, which was initially named 2019 novel coronavirus (2019-nCoV), and then finally called severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) ( 4). Some patients rapidly developed acute respiratory stress syndrome (ARDS), acute respiratory failure, and other serious systemic complications. Since December 2019, several cases of interstitial pneumonia have been reported in the city of Wuhan, a metropolis in the Chinese province of Hubei ( 3). Received: 06 October 2020 Accepted: 25 October 2020 Published: 30 January 2021.Ĭoronaviruses are a large family of viruses which are known to cause a vast array of diseases, ranging from common cold to more serious conditions such as Severe Acute Respiratory Syndrome (SARS) and Middle Eastern Respiratory Syndrome (MERS) ( 1, 2). Keywords: COVID-19 severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Total cholesterol high-density lipoprotein (HDL)-cholesterol high-density lipoprotein (HDL)-cholesterol triglycerides lipid raft Moreover, lipid abnormalities observed during and after this infection could be used for assessing indirectly the response to clinical treatment. C-reactive protein levels were found to be inversely correlated with those of LDL-cholesterol (rs =–0573, P<0.0001), total cholesterol (r=–0.732, P<0.0001), and HDL-cholesterol (r=–0.700, P<0.0001).Ĭonclusions: The results of our study seemingly attest that lipids, especially cholesterol, may play an important role in viral replication, internalization and immune activation in patients with COVID-19 infection. Total cholesterol, HDL-cholesterol, LDL-cholesterol and triglyceride were found to be significantly higher after recovery than during the acute phase of infection (P<0.0001). Comparing healthy controls and the group after, statistically significant differences were observed for all parameters except for total cholesterol (P=0.9006). Results: LDL-cholesterol, HDL-cholesterol, total cholesterol levels were significantly lower in COVID-19 patients (Group before) as compared with normal subjects (P<0.0001). The laboratory tests results were compared between these two groups, as well as with a group of healthy subjects (Healthy controls), matched for age and sex and selected among the blood donors. The lipid profile and the hematological parameters were analyzed in the same group of patients before (Group before) and after clinical management (Group after). Methods: A retrospective study was performed to examine serum levels of LDL-cholesterol, HDL-cholesterol, total cholesterol and triglycerides on 55 COVID-19 patients who were hospitalized in our center between February and April 2020. Policy of Dealing with Allegations of Research Misconductīackground: In this study, we aimed to investigate the pathological alterations of LDL-cholesterol, HDL-cholesterol, total cholesterol and triglycerides in COVID-19 patients during the acute phase of infection, and after recovery.Policy of Screening for Plagiarism Process.
0 kommentar(er)
